SIGA Technologies Inc.

SIGA TECHNOLOGIES NAMED TO DELOITTE TRI-STATE AREA TECHNOLOGY FAST 50

Thursday 23 October 2008

SIGA Is a Four-Time Winner of the Award

NEW YORK, OCTOBER 23, 2008 – SIGA Technologies, Inc. (Nasdaq: SIGA),

specializing in the development of pharmaceutical agents to fight bio-warfare pathogens, today

announced that it has been selected as a winner of the Deloitte New York, New Jersey,

Connecticut Technology Fast 50 Program for 2008.

The regional award, which recognizes the 50 fastest growing technology, media,

telecommunications and life sciences companies in the Tri-State area, based on percentage

revenue growth over five years, ranked SIGA as 44 on the list. The award was presented to the

company on October 22 at the Metropolitan Club in New York City.

The Fast 50 is an annual election of the 50 fastest growing technology companies. The selection

will be based on the percentage revenue growth over the past five years (2003 to 2007).

Participants may come from the public and private sector technology and include all segments

including software, Internet, biotech/life sciences, computers/peripherals, semiconductors,

communications/networking and media/entertainment.

SIGA’s revenues have come in the form of grants and contracts from the government that support

the research and development of the company’s product pipeline, most importantly its lead

product candidate, ST-246, an antiviral for orthopox viruses. Over recent years, the government

has increased its support for SIGA’s products, as ST-246 and other drug candidates have

continued to move through the development pipeline. In recent weeks, the government has

provided additional support to SIGA in the form of four contracts totaling approximately $80

million.

Commenting on the award, Dr. Eric A. Rose, SIGA’s Chairman and Chief Executive Officer,

stated, “This recognition speaks to the continued support that the government has provided in our

efforts to develop a pipeline of products to protect and defend against the threat of bio-warfare.

We will use the more recent monetary contributions from the government to further our product

pipeline, most notably our lead product candidate, ST-246.”

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About SIGA Technologies, Inc.

SIGA Technologies is applying viral and bacterial genomics and sophisticated computational

modeling in the design and development of novel products for the prevention and treatment of

serious infectious diseases, with an emphasis on products for biological warfare defense. SIGA

believes that it is a leader in the development of pharmaceutical agents to fight potential biowarfare

pathogens. SIGA has antiviral programs targeting smallpox and other Category A

pathogens, including arenaviruses (Lassa fever, Junin, Machupo, Guanarito, Sabia, and

lymphocytic choriomeningitis), dengue virus, and the filoviruses (Ebola and Marburg). For more

information about SIGA, please visit SIGA’s Web site at

http://www.siga.com/.

Forward Looking Statement

This press release contains or implies certain “forward-looking statements” within the

meaning of the Private Securities Litigation Reform Act of 1995, as amended, including

statements regarding the efficacy of potential products, the timelines for bringing such

products to market and the continued development and possible eventual approval of

such products. Forward-looking statements are based on management’s estimates,

assumptions and projections, and are subject to uncertainties, many of which are beyond

SIGA’s control. Actual results may differ materially from those anticipated in any

forward-looking statement. Factors that may cause such differences include the risks that

(a) potential products that appear promising to SIGA or its collaborators cannot be shown

to be efficacious or safe in subsequent pre-clinical or clinical trials, (b) SIGA or its

collaborators will not obtain appropriate or necessary governmental approvals to market

these or other potential products, (c) SIGA may not be able to obtain anticipated funding

for its development projects or other needed funding, (d) SIGA may not be able to secure

funding from anticipated government contracts and grants, (e) SIGA may not be able to

secure or enforce sufficient legal rights in its products, including sufficient patent

protection for its products and (f) regulatory approval for SIGA’s products may require

further or additional testing that will delay or prevent approval. More detailed

information about SIGA and risk factors that may affect the realization of forwardlooking

statements, including the forward-looking statements in this press release, is set

forth in SIGA’s filings with the Securities and Exchange Commission, including SIGA’s

Annual Report on Form 10-K for the fiscal year ended December 31, 2007, and in other

documents that SIGA has filed with the Commission. SIGA urges investors and security

holders to read those documents free of charge at the Commission’s Web site at

http://www.sec.gov. Interested parties may also obtain those documents free of charge

from SIGA. Forward-looking statements speak only as to the date they are made, and,

except for any obligation under the U.S. federal securities laws, SIGA undertakes no

obligation to publicly update any forward-looking statement as a result of new

information, future events or otherwise.

Contact:

KCSA Strategic Communications

Todd Fromer / Marybeth Csaby / David Burke

212-896-1215 / 1236 / 1258

Tfromer@kcsa.com / mcsaby@kcsa.com / dburke@kcsa.com